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Poliposis adenomatosa familiar de origen no filiado: Identificación de nuevos genes de predisposición al cáncer colorrectal mediante secuenciación de exomas

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This project aims to advance the knowledge on the landscape of susceptibility variants and genes across several cancers in large cohorts of patients. To this end, we have the ambitious goal to mine the pan cancer panel of the International Cancer Genome Consortium (ICGC)/The Cancer Genome Atlas (TCGA), and to replicate the resulting candidate genes in an independent large cohort…

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Project abstract: Long-term side-effects of radiotherapy impact on the quality-of-life (QoL) of cancer survivors. These side-effects could be reduced if predicted in advance. Previous work identified clinical and biological predictors but a major, coordinated approach is needed to validate them so they can be used clinically. The EU has ~17.8 million people living with a prior diagnosis of cancer…

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Radiogenómica: evaluación de variantes raras asociadas a toxicidad radioinducida e identificación de variantes causales mediante Fine-mapping

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