Psyquiatric Diseases Genetics


Main researcher:  Javier Costas Costas

Search for rare variations prone to schizophrenia through the analysis of non-synonymous single nucleotide polymorphisms (nsSNPs). Verify if the accumulation of rare variations in candidate functional genes increases the considerably higher predisposition of suffering schizophrenia than the different common variations for the described susceptibility. This approximation is carried out in proteins involved in the synaptic transmission and development of the central nervous system, for example DISC1 and its interactome.

Search for allelic variations that facilitate an early diagnosis of the disease.

Identify the subtypes of schizophrenia with molecular basis. Identify the functional pathways or specific protein complex that present an accumulation of rare variations susceptible to schizophrenia.

Study of the genetic susceptibility to postpartum depression as an interaction model between genetic and environmental factors.

Identify genetic factors involved in the susceptibility and in the pharmacologic response of mental diseases using next generation sequencing (NGS) techniques.


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